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Some infections come in repeated epidemic waves, others are new to human populations. Some mutate or species jump. It depends on the route of transmission. A lecture by Christopher Whitty, Gresham Professor of Physic 10 October 2018 6pm (UK time) https://www.gresham.ac.uk/lectures-an… Some infections come in repeated epidemic waves, others are new to human populations. A known human threat such as influenza may mutate or a new infection jumps the species barrier from animals to humans: recent examples include HIV and Ebola, and the historical example of plague. What happens depends on the route of transmission. Methods for tackling an airborne disease like influenza are different from those for touch (Ebola), insect vector (Zika), water (cholera) or sexual transmission (HIV).